Substance use, including opioid use, increased during the COVID-19 pandemic.1 While overall emergency department visits decreased during the pandemic, nonfatal opioid overdose visits more than doubled, but few patients who overdosed on opioids received naloxone prescriptions on discharge.2 Studies show that increased access to naloxone can reduce fatal overdoses.In this study, we analyze the trends in filled naloxone prescriptions during the COVID-19 pandemic in the United States and compare these with trends in opioid prescriptions and overall prescriptions.